10 By enhancing serotonergic transmission, SSRIs can activate GABA interneurons, thereby dampening the noradrenergic and dopaminergic input. 9Įmotional blunting is related to SSRI dose, 9,10 and possibly serotonergic effects on the frontal lobes and/or serotonergic modulation of midbrain dopaminergic systems projecting to the prefrontal cortex (PFC). The primary effect of SSRIs is reduced processing of negative stimuli rather than increased positive stimuli. Higher doses of SSRI are more likely to cause emotional blunting 9,10
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